Clinical Signs:
Painful Sensarions, Usually Localized to Hands and Feet

The most common causative agents of peripheral neuropathy are the vinca alkaloids (vincristine), cisplatin, and procarbazine. The neuropathy is typically manifested by painful paresthesia and occasionally motor and sensory losses.

The painful sensations are usually localized to the hands and feet.

Steroid pseudorheumatism is caused by withdrawal of patients from corticosteroids. It is manifested by diffuse arthralgia check this and myalgia.

Pathophysiology of the pain is unknown.

Chronic steroid therapy can cause necrosis of the femoral and humeral heads. Clinical presentation is in the knee, shoulder, or leg, exacerbated by movement and relieved by rest.

Bone scans are the most sensitive diagnostic tool. Occasionally CT or MR scan can be useful in diagnosis.