The Breast Cancer Gene Mural

Version 0.5

© MM-MMV• WDV
 
DNA
Repair
MMTV
integration
sites
oncogenes
transcription
factors
cell
cycle
tumor
suppressors
growth factors

hormone
receptors
(also TF's)

external
signaling
internal
signaling
cell surface
proteins
cell- cell
adhesion
cell-cell
adhesion
drug
resistance
ERBA thy
close to
calveolins
receptor
mediated
caveolins
cadherins
integrins
ERBB egf

immuno-
globulin
mediated oncogene

developmental
signaling
kinase
ERBB2 tyrk
 
ERBB3
her3
 
programmed
cell death
surface-borne
tumor supressor
 
 
EAR1
ERBA
 
tyrosine
kinase
receptor
excision
viral
oncogenes
 
EAR2
ERBA
 
extracellularly
stimulated

putative
multifactorial
develop.

programs

hormone
sensitive
growth factors
macrophage
scavanger
receptors
 
DNA
Breakpoint
ubiquination

APC

macrophage
interaction
 
catenins
EAR3 ERBA
   
oncofetal
genes
   
GCCR ERBA
 
MMP
(collagenase)
shuttling
 
cyclin
dependent
kinases
   
Xeroderma
Pigmentosum
 
p53
downreg.
NR1D2 ERBA
     
           
       
insulin-like
growth factor
   
lymph
node
homing
 
               
                 
                 
                 
         
interleukins
         
     
telomere
maintenance
BC
Suppressors
           
                     
                       
Putative
DNA
Repair
                       
                         
                         
  Mural by Van Warren MS CS, AE © 2005
as of
2/7/2005
6/17/2005
OMIM "Gene" Matches
12377
12642
OMIM "Breast Cancer Genes"
305
315
OMIM "Tumor Supressors"
84
87
OMIM "Breast Cancer Oncogenes"
37
39