|  
        
          Acetyl-Coenzyme A : CAS 72-89-9  
        
         Efficient 
          Synthesis of Radiolabeled Propionyl-Coenzyme A and Acetyl-Coenzyme A    
           
          -- excerpted from Priestly    
         PDB 
          File      
          -- 
          excerpted from Klotho: 
          Biochemical Compounds Declarative Database 
        | 
    
     
      |  
        
          Lovastatin:  CAS 75330-75-5  
        
         Appelkvist 
          EL et al.: Effects of Inhibitors of HMG-CoA Reductase on CoQ10 and 
          Dolichol Biosynthesis. (1993)     
          Bargossi 
          A M et al.: Exogenous CoQ10 administration prevents plasma ubiquinone 
          reduction induced by HMG-CoQ reductase inhibitors (1993)    
           
          Bargossi 
          AM et al.: Exogenous CoQ10 Supplementation Prevents Plasma Ubiquinone 
          Reduction Induced by HMG-CoA Reductase Inhibitors (1994)    
           
          Bargossi 
          AM et al.: Antioxidant effects of exogenous ubiquinone (Q10) in 
          high level endurance runners (1993)     
          Ghirlanda 
          G et al.: Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase 
          inhibitors: A double-blind, placebo-controlled study (1993)    
           
          Laaksonen 
          R: The effect of HMG-CoA reductase inhibitor treatment on serum 
          and skeletal muscle ubiquinone (1996)     
          Willis 
          RA et al.: The reduction of tissue levels of coenzyme Q in rats 
          by lovastatin, an HMG-CoA reductase inhibitor (1991)    
           
          -- excerpted from Pharma 
          Nord, (which has a number of ubiquinone entries also)    
         Mechanism 
          of HMG-CoA Reductase. New Role of Lys-267 Revealed in the Ternary Complex 
          Structures. Lydia Tabernero     
          Binary 
          Complexes of HMG-CoA Reductase: Elements of Substrate Binding in Catalysis. 
          Jeff Watson     
          -- excerpted from ACA 
          97 Abstracts    
         Chime Model    
           
          -- excerpted from Figures, 
          Animations, and Structures Used in NetPharmacology 
        | 
    
     
       
        
           Mevalonate
        
        Introduction 
        to Cholesterol Metabolism     
        -- excerpted from "The Site For Medical Biochemistry" | 
    
     
      |  
        
          Mevalonate Kinase 
        
        Molecular 
        cloning of human mevalonate kinase and the 
        genetic disease mevalonic 
        aciduria.    
         -- link from     
          Schafer BL, Bishop RW, Kratunis VJ, Kalinowski 
          SS, Mosley ST, Gibson KM, Tanaka RD     
          J Biol Chem 1992 Jul 5;267(19):13229-13238    
           
            
        | 
    
     
       
        
          HMG-CoA 
        
        listed in CambridgeSoft 
        database under the synonym:     
        "3-Hydroxy-3-methylglutaryl-CoA" | 
    
     
       
        
          Isopentenyl 
          pyrophosphate 
        
        listed in CambridgeSoft 
        database under the synonym:     
        "Isopentenyl diphosphate"    
        
            
        
       | 
    
     
       
        
          Geranyl 
          Pyrophosphate 
        
        listed in CambridgeSoft 
        database under the synonym:     
        "Monoterpenyl diphosphate"    
         
          | 
    
     
       
        
          Squalene 
        
        What 
          is Squalene and Squalane?     
          Cholesterol 
          Biosynthesis     
          Novel 
          approaches to squalene biosynthesis     
          Sources 
          in Agriculture and Fisheries    
          Steroids, 
            Lipids and Prostaglandins     
            Lipid 
            Biosynthesis     
            Biochemical 
            Insights from Plant-Pathogen Interactions    
             
            Plant 
            Terpenoid Bionsynthesis     
            Sterol 
            biosynthesis     
            Ursodeoxycholic 
            Acid on Serum and Biliary Noncholesterol    
             
            Antifungal 
            Agents    
           -  Pharmacological 
            Effects of Lipids: Chewin' the Fat, Seein' Things
 
          -  Dr. 
            P.G.Steel: LordOSynth: Squalestatin: Inhibitor of Squalene Synthesis.
 
           
          Dr. 
          Richard A. Gibbs: J.Willard's legacy: Ras proteins,  Deuterated 
          analogs of FPP.     
          Dr. 
          Dale Poulter: Enzyme-catalyzed transformations in isoprene biosynthetic.    
           
          Tim 
          Devarenne: Fame and fortune on the isoprenoid pathway.    
           
          Eric 
          Jan Leopold: Organic Synthesis Dude.     
          Connolly, 
          Erin : Characterization of isoprenoid biosynthesis    
           
              
          -  Trypanosoma 
            Cruzi
 
           
          Trypanosoma 
          Brucei     
          S. 
          cerevisiae sequencing    
          Smith-Lemli-Optiz 
            Syndrome Bibliography     
                 
            -- links excerpted from Excite 
            &  Alta-Vista  
          
       | 
    
     
      |  
        
          Squalene 
          Epoxidase (Squalene Synthase) 
        
         Squalene 
          Epoxidase Overview   
          More 
          Squalene Epoxidase Links: Hit Retrieve Button At Top of Page  
           
          Terbinafine: 
          Squalene Epoxidase Inhibitors   
          Localization 
          of the squalene epoxidase gene in humans 
        | 
    
     
       
        
          Dolichols & Isoprenoids 
        
        Edward 
        Kean     
        J.W. 
        RIP   
        Sally 
        Nyquist   
        W. 
        Lee Adair   
        R. 
        Ken Keller    
        Thierry 
        Grard   
        Josef 
        Brunner    
        Effects 
          of homoharringtonine on protein glycosylatio...    
           
          Yeast 
          Protein Database    
         Dolichol 
          on Dry Ice To Go    
          Glycoproteins   
         Molecular 
          and Cellular Endocrinology, Volume 122 Issue 2     
           
          DEPARTMENT 
          OF LIPID BIOCHEMISTRY   
            
        | 
    
     
       
        
          Ubiquinones 
        
        Asha Pharma 
        Coenzyme Q10     
        CoEnzyme 
        Q1O   
        CoEnzyme 
        Q10 Page  
        Molecular 
          Aspects of Medicine, Volume 18 Issue 1001   
          Pharma 
          Nord Research Manual   
          CoQ10 
          & Heart Disease   
          Dyna-Lode 
          with Coenzyme Q-10   
          PNAS 
          Enhanced sensitivity of ubiquinone-deficient mutants of Saccharom...   
           
             
            
        | 
    
     
       
        
           Resources
        
         Welcome 
          to CambridgeSoft! 
         Chemistry 
          Links Index 
         Making 
          Chime Work 
         Molecular 
          Biology Servers/Databases/Web Sites of Interest 
         This 
          chart was created by Evgeni Selkov (evgeni@mcs.anl.gov). 
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          - Biochemical Pathways 
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          nucleotide query 
         Broker 
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         Query 
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          for PDB query 
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          List Request 
         Biochemical 
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         Pharma 
          Nord Research Manual 
          The Site for Medical Biochemistry
         
        How 
          to Sequence Proteins
         
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        Entrez 
          Search for Nucleotides, Proteins, 3D Structures, Genomes, Taxonomy, 
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        Major 
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          Example: What makes Tachykinin? 
           
          BioBM 
          233: Introduction to Biomolecular Structure 
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        Nice 
          Little Neurotransmitters and Inhibitors Collection 
        Chemistry 
          Software and 3D Databases! 
        Animation 
          Example 
        Complete 
          Protein Data Bank Index     
          find the index code for the protein you want, 
          then lookup the pdb file with that code.    
         HET 
          groups listing   
          http://www.pdb.bnl.gov/pdb-docs/hetMDL/UQ1.pdb  
          ubiquinone    
          http://www.pdb.bnl.gov/pdb-docs/hetMDL/HEM.pdb 
          heme     
            
        |