Isoprenoid Pathway Substance References
 
Acetyl-Coenzyme A : CAS 72-89-9 

Efficient Synthesis of Radiolabeled Propionyl-Coenzyme A and Acetyl-Coenzyme A   
-- excerpted from Priestly   

PDB File    
-- excerpted from Klotho: Biochemical Compounds Declarative Database

Lovastatin:  CAS 75330-75-5 

Appelkvist EL et al.: Effects of Inhibitors of HMG-CoA Reductase on CoQ10 and Dolichol Biosynthesis. (1993)   
Bargossi A M et al.: Exogenous CoQ10 administration prevents plasma ubiquinone reduction induced by HMG-CoQ reductase inhibitors (1993)   
Bargossi AM et al.: Exogenous CoQ10 Supplementation Prevents Plasma Ubiquinone Reduction Induced by HMG-CoA Reductase Inhibitors (1994)   
Bargossi AM et al.: Antioxidant effects of exogenous ubiquinone (Q10) in high level endurance runners (1993)   
Ghirlanda G et al.: Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double-blind, placebo-controlled study (1993)   
Laaksonen R: The effect of HMG-CoA reductase inhibitor treatment on serum and skeletal muscle ubiquinone (1996)   
Willis RA et al.: The reduction of tissue levels of coenzyme Q in rats by lovastatin, an HMG-CoA reductase inhibitor (1991)   
-- excerpted from Pharma Nord, (which has a number of ubiquinone entries also)   

Mechanism of HMG-CoA Reductase. New Role of Lys-267 Revealed in the Ternary Complex Structures. Lydia Tabernero   
Binary Complexes of HMG-CoA Reductase: Elements of Substrate Binding in Catalysis. Jeff Watson   
-- excerpted from ACA 97 Abstracts   

Chime Model   
-- excerpted from Figures, Animations, and Structures Used in NetPharmacology

Mevalonate
Introduction to Cholesterol Metabolism   
-- excerpted from "The Site For Medical Biochemistry"
Mevalonate Kinase
Molecular cloning of human mevalonate kinase and the genetic disease mevalonic aciduria.   

-- link from   
Schafer BL, Bishop RW, Kratunis VJ, Kalinowski SS, Mosley ST, Gibson KM, Tanaka RD   
J Biol Chem 1992 Jul 5;267(19):13229-13238   
 

HMG-CoA
listed in CambridgeSoft database under the synonym:   
"3-Hydroxy-3-methylglutaryl-CoA"
Isopentenyl pyrophosphate
listed in CambridgeSoft database under the synonym:   
"Isopentenyl diphosphate"   
 
Geranyl Pyrophosphate
listed in CambridgeSoft database under the synonym:   
"Monoterpenyl diphosphate"   
 
Squalene
What is Squalene and Squalane?   
Cholesterol Biosynthesis   
Novel approaches to squalene biosynthesis   
Sources in Agriculture and Fisheries   

Steroids, Lipids and Prostaglandins   
Lipid Biosynthesis   
Biochemical Insights from Plant-Pathogen Interactions   
Plant Terpenoid Bionsynthesis   
Sterol biosynthesis   
Ursodeoxycholic Acid on Serum and Biliary Noncholesterol   
Antifungal Agents   

Pharmacological Effects of Lipids: Chewin' the Fat, Seein' Things
Dr. P.G.Steel: LordOSynth: Squalestatin: Inhibitor of Squalene Synthesis.

Dr. Richard A. Gibbs: J.Willard's legacy: Ras proteins,  Deuterated analogs of FPP.   
Dr. Dale Poulter: Enzyme-catalyzed transformations in isoprene biosynthetic.   
Tim Devarenne: Fame and fortune on the isoprenoid pathway.   
Eric Jan Leopold: Organic Synthesis Dude.   
Connolly, Erin : Characterization of isoprenoid biosynthesis   
   
Trypanosoma Cruzi

Trypanosoma Brucei   
S. cerevisiae sequencing   

Smith-Lemli-Optiz Syndrome Bibliography   
   
-- links excerpted from Excite &  Alta-Vista 

Squalene Epoxidase (Squalene Synthase)

Squalene Epoxidase Overview 
More Squalene Epoxidase Links: Hit Retrieve Button At Top of Page 
Terbinafine: Squalene Epoxidase Inhibitors 
Localization of the squalene epoxidase gene in humans

Dolichols & Isoprenoids
Edward Kean   
J.W. RIP 
Sally Nyquist 
W. Lee Adair 
R. Ken Keller  
Thierry Grard 
Josef Brunner   

Effects of homoharringtonine on protein glycosylatio...   
Yeast Protein Database   

Dolichol on Dry Ice To Go  
Glycoproteins  

Molecular and Cellular Endocrinology, Volume 122 Issue 2    
DEPARTMENT OF LIPID BIOCHEMISTRY 
 

Ubiquinones
Asha Pharma Coenzyme Q10   
CoEnzyme Q1O 
CoEnzyme Q10 Page 

Molecular Aspects of Medicine, Volume 18 Issue 1001 
Pharma Nord Research Manual 
CoQ10 & Heart Disease 
Dyna-Lode with Coenzyme Q-10 
PNAS Enhanced sensitivity of ubiquinone-deficient mutants of Saccharom...  
 
 

Resources
Welcome to CambridgeSoft! 
Chemistry Links Index 
Making Chime Work 
Molecular Biology Servers/Databases/Web Sites of Interest 
This chart was created by Evgeni Selkov (evgeni@mcs.anl.gov). 
Molecular Biology Servers/Databases/Web Sites of Interest 
Listings for PDB Heterogens and Their Codes 
NEW SRS:Select Libraries Page 
ExPASy - ENZYME top page 
Biochemical Pathways - Map No. E10 
ExPASy - Biochemical Pathways 
Human Genome Project Information 
PubMed nucleotide query 
Broker Query Results for: ubiquinone 
Query Interface to the PDB Broker 
Research Tools on the Network 
Form for PDB query 
PIR List Request 
Biochemical Pathways - Map No. D8 E8 
Pharma Nord Research Manual
The Site for Medical Biochemistry
 
How to Sequence Proteins
 
Cancer Genome Anatomy Project
 
Entrez Search for Nucleotides, Proteins, 3D Structures, Genomes, Taxonomy, Literature
 
Major Biotech Databases
 
Corina Structure Builder
 
Genome Example: What makes Tachykinin?

BioBM 233: Introduction to Biomolecular Structure
Links For Chemists (> 6000)
UK Mol File Searcher

Nice Little Neurotransmitters and Inhibitors Collection

Chemistry Software and 3D Databases!

Animation Example

Complete Protein Data Bank Index   
find the index code for the protein you want, then lookup the pdb file with that code.   

HET groups listing 
http://www.pdb.bnl.gov/pdb-docs/hetMDL/UQ1.pdb  ubiquinone  
http://www.pdb.bnl.gov/pdb-docs/hetMDL/HEM.pdb heme