1 · Simulation & Dosing Controls
0 = single12h24h48h72h168h = q7d
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Enzyme / Pathology Modulators
Clinical Presets
2 · Biochemical Graph & Anatomical PBPK Overlay
Pathway Legend — nodes
Dose/GIoral input · k_a absorption
DHEAdehydroepiandrosterone · free effector · t½ 15–30 min
DHEA-SDHEA sulfate · reservoir · t½ 10–20 h
7-OH7α/7β-hydroxy-DHEA · neurosteroid (CYP7B1)
A4androstenedione · Δ4 branchpoint (HSD3B)
Ttestosterone · AR agonist (HSD17B3)
DHTdihydrotestosterone · potent AR ligand (SRD5A)
E1/E2estrone / estradiol (CYP19A1 aromatase)
Elimhepatic (fast) + renal (slow) sinks
Metabolic switches: the live % splits at A4 and T decide androgen-vs-estrogen fate — they shift with sex, age, and the inhibitor sliders.
Mechanism Inspector
Hover or tap any node, enzyme label, switch readout, or organ to inspect mechanism, kinetics, EC / OMIM references, feedback loops, live flux, and the full symbol glossary.3 · Dynamic PK / PD Analytics
━ DHEA (ng/mL, left) ━ DHEA-S (µg/dL, right) · shaded bands = reference ranges · ╌ ghost = snapshot
Downstream tissue indices (× baseline): ━ T ┅ DHT ┈ E1/E2 ╌ Neurosteroid
Adverse-Effect Load (AUC-weighted, full horizon)
Androgenic load — DHT AUC (acne · hirsutism · alopecia · prostate)0%
Estrogenic load — E1/E2 AUC (gynecomastia · VTE · breast)0%
Neurosteroid–Psychopharmacology Module (at time t)
GABA-A receptor inhibition — DHEA negative allosteric modulation0%
NMDA / σ1 excitatory tone (free DHEA + 7-OH-DHEA)0%
DHEA C_max / T_max
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DHEA-S C_max / T_max
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AUC DHEA
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AUC DHEA-S
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Reservoir buffering ratio (molar AUC)
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Effective t½ (terminal λz, DHEA-S)
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Apparent t½ free DHEA (flip-flop tail)
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Accumulation ratio R_ac (DHEA-S)
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