"CD44 receptor protein" "is a" "integral cell membrane glycoprotein"
"CD44 receptor protein" "has a role in" "matrix adhesion lymphocyte activation"
"CD44 receptor protein" "is a synonym for" "lymph node homing receptor"
"CD44 receptor protein" "has molecular weight" "37-kD"
"CD44 receptor protein" "is homologous to" "cartilage link protein"
"CD44 receptor protein" "is the cell surface receptor for" "hyaluronate"
"human lymphocyte" "migrate selectively from" "the bloodstream"
"human lymphocyte" "migrate selectively to " "different lymphatic tissues"
"human lymphocyte" "migrate through" "specialized high endothelial venules"
"HEV" "is a synonym for" "high endothelial venules"
"lymph node homing receptor" "are on the surface of" "human lymphocytes"
"lymph node homing receptor" "interact specifically with" "HEV"
"lymph node homing receptor" "play a central role in" "cell migration"
"lymph node homing receptor" "has molecular weight" "85-95 kD"
"lymph node homing receptor" "is assigned to" "11pter-p13"
"CD44 receptor gene" "codes for" "CD44 receptor protein"
"lymph node homing receptor" "is assigned to" "11pter-p13"
"Human parent cells" "had various deletions of" "human chromosome 11"
"CD44 receptor protein" "is same as " "human leukocyte surface glycoprotein"
"human leukocyte surface glycoprotein" "is a synonym" "CDw44"
"CD44 receptor protein" "is same as" "Pgp-1 glycoprotein"
"The erythrocyte antigen" "is inhibited by" "In(Lu) gene"
"the A3D8 antigenic property" "resides on" "red cell membrane protein"
"red cell membrane protein" "has molecular weight" "80-kD"
"red cell membrane protein" "is present in" " trace amounts"
"red cell membrane protein" "is present in" "In(Lu) Lu(a-b-) red cells"
"A3D8" "has corresponding" "antigens"
"A1G3" "has corresponding" "antigens"
"genes on 11p" "determine" "antigens"
"A1G3" "is " "a monoclonal antibody"
"A3D8" "is" "a monoclonal antibody"
"A1G3" "binds to" "different epitopes"
"A3D8" "binds to" "different epitopes"
"different epitopes" "are on" "red cell membrane protein"
"A3D8" "recognized" "MDU3 antigen"
"MDU3 antigen" "is a synonym for" "monoclonal Duke University 3"
"monoclonal Duke University 3" "is a synonym for" "CD44 receptor protein"
"MC56" "is a" "drug-sensitivity marker"
"MC56," "is mapped to" "11pter-p13"
"CD44 receptor protein" "may function as" "lymphocyte homing receptor"
"the gene that maps to chromosome 11" "is distinct from" "lymph node homing receptor"
"lymph node homing receptor" "is located on" "chromosome 1 (153240)"
"mouse gene Ly-24" "codes for" "lymph node homing receptor"
"CD44 gene" "contains" "19 exons"
"CD44 gene" "is made of" "CD44 exons"
"CD44 exons" "span" "50 kb of genomic DNA"
"CD44 exons" "include within the extracellular domain" "10 alternatively spliced exons"
"2 CD44 exons" "utilize" "internal splice donor and acceptor sites"
"CD44 exons" "include" "2 CD44 exons"
"2 CD44 exons" "alternative splicing causes" "variation in the cytoplasmic domain"
"CD44 gene" "is" "remarkably complex"
"CD44 gene" "exhibits" "alternative splicing"
"CD44 alternative splicing" "causes" "structural diversity"
"CD44 alternative splicing" "causes" "functional diversity"
"CD44 alternative splicing" "causes" "CD44 splice variants"
"CD44 splice variants" "may be associated with" "metastases"
"CD44 splice variants" "may be useful in" "the early detection of metastatic potential in surgical biopsy specimens"
"CD44 splice variants" "may be useful in" "the early diagnosis of cancer in screening program"
"CD44 splice variants" "may be useful in" "assessment of remaining disease"
"CD44 splice variants" "may be useful in" "early detection of recurrence"
"CD44 receptor protein" "is not found in" "normal gastric mucosa"
"CD44 receptor protein" "is found in" "only 49% of primary tumors"
"CD44 receptor protein" "was associated with" "distant metastases"
"CD44 receptor protein" "was associated with" "tumor recurrence"
"CD44 receptor protein" "was associated with" "increased mortality from gastric cancer"
"CD44 gene" "codes for" "CD44 receptor protein"
"CD44 receptor protein" "is expressed as" "certain CD44 isoforms"
"family of molecular isoforms" "are generated from" "alternative RNA splicing"
"family of molecular isoforms" "are generated from" "posttranslational modifications"
"certain CD44 isoforms" "regulate activation of" "lymphocytes"
"certain CD44 isoforms" "regulate migration of" "lymphocytes"
"certain CD44 isoforms" "regulate migration of" "macrophages"
"certain CD44 isoforms" "may enhance" "local growth"
"certain CD44 isoforms" "may enhance" "distant metastases"
"hyaluronic acid" "is a ligand of" "CD44 receptor protein"
"hyaluronic acid" "binds to" "NH2-terminal domain of CD44"
"hyaluronic acid" "enhances" "cellular aggregation"
"hyaluronic acid" "enhances" "tumor cell growth"
"CD44 receptor protein" "is a synonym for" "hyaladherin"
"osteopontin" "is a ligand of" "CD44 receptor protein"
"osteopontin" "induces" "chemotaxis"
"hyaluronate" "induces" "homotypic aggregation of cells"
"CD44 + hylauronate" "may be exploited by" "tumor cells"
"CD44 + hylauronate" "may allow" "OPN-mediated metastatic spread"
"CD44 + hylauronate" "may allow" " metastatic growth"
"CD44 receptor protein" "has a role in" "in early limb development"
"CD44 receptor protein" "is expressed by" "limb bud cells"
"limb bud cells" "include" "apical ectodermal ridge"
"CD44 splice variants" "are generated from" " a single gene"
"CD44 splice variants" "are generated by" "alternative RNA splicing"
"10 CD44 exons" "participate in" "alternative RNA splicing"
"CD44 exons" "include" "10 CD44 exons"
"CD44 splice variants" "are generated" "by extensive posttranslational modifications"
"amino acid sequences" "are encoded by" "CD44 splice variants"
"CD44 splice variants" "codes for variation in" "extracellular portion of protein"
"extracellular portion of the protein" "is near" "transmembrane domain"
"CD44 standard form protein" "lacks" "variant sequences"
"CD44 standard form protein" "is" "smallest"
"CD44 standard form protein" "is expressed by" "numerous cell types"
"CD44 standard form protein" "carries" "no variant exon sequences"
"CD44 splice variants" "are expressed in" "a limited number of tissues"
"CD44 splice variants" "are expressed in" "only in certain tumors"
"AER" "is a synonym for" "apical ectodermal ridge"
"AER" "sends" "signals"
"signals" "include" "fibroblast growth factor-8"
"FGF8" "is a synonym for" "fibroblast growth factor-8"
"signals" "can maintain proliferation in" "limb mesenchymal cells"
"CD44 splice variants" "include" "specific CD44 splice variant"
"specific CD44 splice variant" "is crucial for" "proliferation of limb mesenchymal cells"
"epitope" "is a synonym for" "antigenic determinant"
"specific CD44 splice variant" "carries" "epitope"
"epitope" "colocalize temporally"
"epitope" "colocalize" "spatially"
"epitope" "colocalize in the AER with" "FGF8"
"epitope" "colocalize throughout" "early limb development"
"specific CD44 splice variant" "contains" "the same sequence expressed on model cells"
"specific CD44 splice variant" "binds" "FGF4"
"specific CD44 splice variant" "binds" "FGF8"
"specific CD44 splice variant" "stimulates" "mesenchymal cells in vitro"
"CD44 epitope" "may have a corresponding" "CD44 epitope antibody"
"CD44 epitope antibody" "when applied to AER blocks" "FGF presentation"
"CD44 epitope antibody" "when applied to AER inhibits" "limb outgrowth"
"CD44 receptor protein" "is necessary for" "limb development"
"CD44 receptor protein" "functions in" "a novel growth factor presentation mechanism"
"CD44 receptor protein" "is relevant when a signal molecule is