"this" "is about" "EGFR gene"
"EGFR gene" "codes for" "EGFR protein"
"this" "has MEDLINE Unique Identifier" "20548722"
"this" "authored by" "Lanzetti L"
"this" "authored by" "Rybin V"
"this" "authored by" "Malabarba MG"
"this" "authored by" "Christoforidis S"
"this" "authored by" "Scita G"
"this" "authored by" "Zerial M"
"this" "authored by" "Di Fiore PP"
"EGFR protein" "is a synonym for" "EGF receptor"
"EGFR protein" "is a synonym for" "EGFR"
"Eps8 protein" "coordinates" "EGFR signalling"
"EGFR signalling" "is coordinated via" "Rac protein"
"Eps8 protein" "coordinates" "EGFR trafficking"
"EGFR trafficking" "is coordinated via" "Rab5 protein"
"Eps8 protein" "coordinates signalling of" "EGFR protein"
"this" "was published" "2000 Nov 16"
"this" "appeared in" "Nature"
"this" "appears on page" "374-7"
"this" "originates in" "ENGLAND"
"this" "has journal issue number" "6810"
"this" "has journal volume number" "408"

"EGFR signalling" "is linked to" "EGFR trafficking"
"small GTPases" "belong to" "Rho protein family"
"small GTPases" "belong to" "Rab protein family"
"EGFR signalling" "involves" "Rho protein family"
"EGFR trafficking" "involves" "Rab protein family"
"Eps8 protein" "is connected to" "EGFR signalling"
"Eps8 protein" "is connected to" "EGFR trafficking"
"Eps8 protein" "is a substrate of" "EGFR protein"
"E3bl protein" "holds in a complex" "Sos1 protein"
"Sos1 protein" "can complex with" "EGFR protein"

"Sos1 protein" "can complex with" "Eps8 protein"

"E3bl protein" "is an" "adapter protein"
"E3bl protein" "mediates activation of" "Rac protein"
"EGFR protein" "complexes with" "Sos1 protein"
"Eps8 protein" "interacts with" "RN-tre protein"
"Eps8 protein" "is homologous to" "src protein"
"Eps8 protein" "has a homology-3 domain in common with" "src protein"

"RN-tre protein" "is a" "Rab5 GTPase-activating protein"
"RN-tre protein" "is regulated by" "EGFR protein"

"RN-tre protein" "complexes with" "Eps8 protein"
"RN-tre protein" "acts on" "Rab5 protein"
"RN-tre protein" "inhibits internalization of" "EGFR protein"

"RN-tre protein" "diverts" "Eps8 protein"
"RN-tre protein" "attenuates" "Rac signalling"
"Eps8 protein" "signals" "EGFR protein"
"EGFR signalling" "takes place via" "Rac protein"
"EGFR trafficking" "takes place via" "Rab5 protein"

"this" "was authored at" "Department of Experimental Oncology",
"this" "was authored at" "European Institute of Oncology"
"this" "was authored at" "
Milan, Italy"
"this" "has PubMed identifier" "0011099046"
"this" "has PubMed identifier" "2000/12/01 11:00"
"this" "added to PubMed database" "2000/12/01 11:00"
"this" "has citation" "Nature 2000 Nov 16;408(6810):374-7"