graph G { size="8,10"; ratio=compress; node [style=filled fontname=Arial fontsize=24];
node []; "insulin-like growth factor" [color= palevioletred1 ];
node []; "Cancer Res 1996 Jun 15;56(12):2781-8" [color= thistle2 ];
node []; "a promoter" [color= lavenderblush3 ];
node []; "dominant-negative p53 protein(248Q)" [color= mediumorchid2 ];
node []; "insulin-like growth factor receptor" [color= plum ];
node []; "breast cancer tumor cells" [color= mintcream ];
node []; "p53 protein" [color= lightgoldenrod ];
node []; "transcription factor" [color= burlywood ];
node []; "this" [color= plum1 ];
node []; "p53 protein" [color= lightgoldenrod ];
node []; "transcription factor" [color= burlywood ];
node []; "transcription process" [color= turquoise2 ];
node []; "insulin" [color= azure3 ];
node []; "insulin-like growth factor" [color= palevioletred1 ];
node []; "mutated p53 protein" [color= lightblue ];
node []; "p53 protein" [color= lightgoldenrod ];
node []; "insulin receptor" [color= peachpuff ];
node []; "protein" [color= plum3 ];
node []; "breast cancer tumor cells" [color= mintcream ];
node []; "normal mammary epithelial cells" [color= cadetblue1 ];
node []; "insulin receptor" [color= peachpuff ];
node []; "insulin receptor promoter" [color= honeydew2 ];
node []; "breast cancer tumor cells" [color= mintcream ];
node []; "Sp1" [color= gray ];
node []; "C/EBP" [color= bisque3 ];
node []; "insulin receptor protein" [color= darkolivegreen1 ];
node []; "[insulin receptor]" [color= lightskyblue2 ];
node []; "[insulin-like growth factor receptor]" [color= greenyellow ];
node []; "insulin receptor" [color= peachpuff ];
node []; "insulin receptor promoter" [color= honeydew2 ];
node []; "tumors" [color= papayawhip ];
node []; "California 92093" [color= deepskyblue ];
node []; "Department of Medicine" [color= lightyellow3 ];
node []; "Division of Endocrinology and Metabolism" [color= lightskyblue2 ];
node []; "La Jolla" [color= lightblue2 ];
node []; "San Diego" [color= antiquewhite ];
node []; "USA" [color= gold1 ];
node []; "University of California" [color= wheat2 ];
node []; "Resnik JL" [color= ivory1 ];
node []; "Haas M" [color= gainsboro ];
node []; "Reichart DB" [color= antiquewhite3 ];
node []; "Seely BL" [color= slategray1 ];
node []; "Strauss B" [color= darkslategray3 ];
node []; "Webster NJ" [color= turquoise ];
"insulin-like growth factor" -- "breast cancer tumor cells" [label= "is required for growth of" fontname="Arial" fontsize=24 color= indigo weight=12];
"C/EBP" -- "p53 protein" [label= "affects" fontname="Arial" fontsize=24 color= salmon4 weight=12];
"C/EBP" -- "transcription factor" [label= "is a" fontname="Arial" fontsize=24 color= violetred4 weight=12];
"Cancer Res 1996 Jun 15;56(12):2781-8" -- "this" [label= "is citation for" fontname="Arial" fontsize=24 color= royalblue4 weight=12];
"Sp1" -- "p53 protein" [label= "affects" fontname="Arial" fontsize=24 color= salmon4 weight=12];
"Sp1" -- "transcription factor" [label= "is a" fontname="Arial" fontsize=24 color= violetred4 weight=12];
"a promoter" -- "transcription process" [label= "increases" fontname="Arial" fontsize=24 color= brown4 weight=12];
"breast cancer tumor cells" -- "insulin" [label= "overexpress" fontname="Arial" fontsize=24 color= blue4 weight=12];
"breast cancer tumor cells" -- "insulin-like growth factor" [label= "overexpress" fontname="Arial" fontsize=24 color= blue4 weight=12];
"dominant-negative p53 protein(248Q)" -- "mutated p53 protein" [label= "is a kind of" fontname="Arial" fontsize=24 color= orangered4 weight=12];
"insulin receptor promoter" -- "p53 protein" [label= "is decreased by" fontname="Arial" fontsize=24 color= gray20 weight=12];
"insulin receptor promoter" -- "insulin receptor" [label= "promotes" fontname="Arial" fontsize=24 color= tomato4 weight=12];
"insulin receptor" -- "protein" [label= "is a" fontname="Arial" fontsize=24 color= violetred4 weight=12];
"insulin receptor" -- "breast cancer tumor cells" [label= "is overexpressed by" fontname="Arial" fontsize=24 color= midnightblue weight=12];
"insulin receptor" -- "normal mammary epithelial cells" [label= "transforms into tumor cells" fontname="Arial" fontsize=24 color= navy weight=12];
"insulin" -- "insulin receptor" [label= "binds to" fontname="Arial" fontsize=24 color= tan4 weight=12];
"insulin" -- "breast cancer tumor cells" [label= "is required for growth of" fontname="Arial" fontsize=24 color= indigo weight=12];
"insulin-like growth factor receptor" -- "breast cancer tumor cells" [label= "antibody blockade decreases" fontname="Arial" fontsize=24 color= deeppink4 weight=12];
"mutated p53 protein" -- "insulin receptor promoter" [label= "does not repress" fontname="Arial" fontsize=24 color= darkslateblue weight=12];
"mutated p53 protein" -- "breast cancer tumor cells" [label= "is associated with" fontname="Arial" fontsize=24 color= blue4 weight=12];
"p53 protein lacking mice" -- "Sp1" [label= "have elevated levels of" fontname="Arial" fontsize=24 color= royalblue4 weight=12];
"p53 protein lacking mice" -- "C/EBP" [label= "have normal levels of" fontname="Arial" fontsize=24 color= chartreuse4 weight=12];
"p53 protein" -- "insulin receptor protein" [label= "inactivation up-regulates expression of" fontname="Arial" fontsize=24 color= forestgreen weight=12];
"p53 protein" -- "[insulin receptor]" [label= "overexpression increases" fontname="Arial" fontsize=24 color= coral4 weight=12];
"p53 protein" -- "[insulin-like growth factor receptor]" [label= "overexpression increases" fontname="Arial" fontsize=24 color= coral4 weight=12];
"p53 protein" -- "insulin receptor" [label= "regulates expression of " fontname="Arial" fontsize=24 color= coral4 weight=12];
"p53 protein" -- "insulin receptor promoter" [label= "represses" fontname="Arial" fontsize=24 color= darkgreen weight=12];
"p53 protein" -- "tumors" [label= "suppresses" fontname="Arial" fontsize=24 color= brown4 weight=12];
"this" -- "California 92093" [label= "authored at" fontname="Arial" fontsize=24 color= violetred4 weight=12];
"this" -- "Department of Medicine" [label= "authored at" fontname="Arial" fontsize=24 color= violetred4 weight=12];
"this" -- "Division of Endocrinology and Metabolism" [label= "authored at" fontname="Arial" fontsize=24 color= violetred4 weight=12];
"this" -- "La Jolla" [label= "authored at" fontname="Arial" fontsize=24 color= violetred4 weight=12];
"this" -- "San Diego" [label= "authored at" fontname="Arial" fontsize=24 color= violetred4 weight=12];
"this" -- "USA" [label= "authored at" fontname="Arial" fontsize=24 color= violetred4 weight=12];
"this" -- "University of California" [label= "authored at" fontname="Arial" fontsize=24 color= violetred4 weight=12];
"this" -- "Resnik JL" [label= "authored by" fontname="Arial" fontsize=24 color= blue4 weight=12];
"this" -- "Haas M" [label= "authored by" fontname="Arial" fontsize=24 color= blue4 weight=12];
"this" -- "Reichart DB" [label= "authored by" fontname="Arial" fontsize=24 color= blue4 weight=12];
"this" -- "Seely BL" [label= "authored by" fontname="Arial" fontsize=24 color= blue4 weight=12];
"this" -- "Strauss B" [label= "authored by" fontname="Arial" fontsize=24 color= blue4 weight=12];
"this" -- "Webster NJ" [label= "authored by" fontname="Arial" fontsize=24 color= blue4 weight=12];
}